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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: USP14 All Species: 17.27
Human Site: S229 Identified Species: 25.33
UniProt: P54578 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54578 NP_001032411.1 494 56069 S229 S V K E T D S S S A S A A T P
Chimpanzee Pan troglodytes P60051 493 55922 S229 S V K E T D S S S A S A A T P
Rhesus Macaque Macaca mulatta XP_001090667 458 52239 P201 S S A S A A T P S K K K S L I
Dog Lupus familis XP_537306 545 61461 S280 S V K E T D S S S A S A V T P
Cat Felis silvestris
Mouse Mus musculus Q9JMA1 493 55983 S229 S G R E T D S S S A P A V T P
Rat Rattus norvegicus NP_001008302 493 55958 S229 S A R E T E S S S A S A V T P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519267 431 48760 P174 G S T A A A P P K K K S L I D
Chicken Gallus gallus XP_419150 492 55612 D227 G D T V M E T D S G A T A T A
Frog Xenopus laevis Q6GNI6 523 60030 L225 L V C E M S T L F Q E F Y S G
Zebra Danio Brachydanio rerio A6H8I0 506 58102 H233 L L H L V W T H A R H L A G Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609377 475 53689 Q216 Q K L R P K N Q E P S N T V Q
Honey Bee Apis mellifera XP_395043 497 56311 A224 L P A K E N L A S E N N G Q S
Nematode Worm Caenorhab. elegans Q17361 489 55859 I206 I M S N V T R I Y G L S G W N
Sea Urchin Strong. purpuratus XP_786966 516 58357 G230 D S I P A V E G A P A A A G A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q949Y0 482 53677 L209 W T Q L L Y T L S Q S L K A P
Baker's Yeast Sacchar. cerevisiae P43593 499 57092 T215 Q D A E E L F T Q L F H S M S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 92.5 89.9 N.A. 96.7 96.5 N.A. 80.3 90.4 21.4 20.1 N.A. 54.6 61.7 41.9 61
Protein Similarity: 100 99.8 92.7 90.2 N.A. 98.5 98.7 N.A. 83.8 94.9 39 38.7 N.A. 71.2 80.2 61.1 76.5
P-Site Identity: 100 100 13.3 93.3 N.A. 73.3 73.3 N.A. 0 20 13.3 6.6 N.A. 6.6 6.6 0 13.3
P-Site Similarity: 100 100 26.6 93.3 N.A. 80 86.6 N.A. 6.6 40 26.6 26.6 N.A. 13.3 33.3 13.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. 43.5 26 N.A.
Protein Similarity: N.A. N.A. N.A. 62.9 46.2 N.A.
P-Site Identity: N.A. N.A. N.A. 20 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 19 7 19 13 0 7 13 32 13 38 32 7 13 % A
% Cys: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 13 0 0 0 25 0 7 0 0 0 0 0 0 7 % D
% Glu: 0 0 0 44 13 13 7 0 7 7 7 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 7 0 7 0 7 7 0 0 0 % F
% Gly: 13 7 0 0 0 0 0 7 0 13 0 0 13 13 7 % G
% His: 0 0 7 0 0 0 0 7 0 0 7 7 0 0 0 % H
% Ile: 7 0 7 0 0 0 0 7 0 0 0 0 0 7 7 % I
% Lys: 0 7 19 7 0 7 0 0 7 13 13 7 7 0 0 % K
% Leu: 19 7 7 13 7 7 7 13 0 7 7 13 7 7 0 % L
% Met: 0 7 0 0 13 0 0 0 0 0 0 0 0 7 0 % M
% Asn: 0 0 0 7 0 7 7 0 0 0 7 13 0 0 7 % N
% Pro: 0 7 0 7 7 0 7 13 0 13 7 0 0 0 38 % P
% Gln: 13 0 7 0 0 0 0 7 7 13 0 0 0 7 7 % Q
% Arg: 0 0 13 7 0 0 7 0 0 7 0 0 0 0 0 % R
% Ser: 38 19 7 7 0 7 32 32 57 0 38 13 13 7 13 % S
% Thr: 0 7 13 0 32 7 32 7 0 0 0 7 7 38 0 % T
% Val: 0 25 0 7 13 7 0 0 0 0 0 0 19 7 0 % V
% Trp: 7 0 0 0 0 7 0 0 0 0 0 0 0 7 0 % W
% Tyr: 0 0 0 0 0 7 0 0 7 0 0 0 7 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _